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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/8488| Reconstructed diagnostic sensitivity and specificity of the RT-PCR test for COVID-19 | |
| Nikhil Padhye | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1101/2020.04.24.20078949 | |
| https://www.medrxiv.org/content/10.1101/2020.04.24.20078949v2 | |
| Real-time reverse transcription polymerase chain reaction (RT-PCR) targeting select genes of the SARS-CoV-2 RNA has been the main diagnostic tool in the global response to the COVID-19 pandemic. This study was aimed at the estimation of diagnostic sensitivity and specificity of the first RT-PCR test developed by China CDC in January 2020. The study design is a secondary analysis of published findings on 1014 patients in Wuhan, China, of whom 59.3% tested positive for COVID-19 in RT-PCR tests and 87.6% tested positive in chest CT exams. We utilized previously ignored expert opinions in the form of verbal probability classifications of patients with conflicting test results to estimate the informative prior distribution of the infected proportion. It was then used in a Bayesian version of a previously developed model to reconstruct the sensitivity and specificity of the diagnostic tests without the need for specifying an inaccurate test as the gold standard. The sensitivity of the RT-PCR diagnostic test was estimated to be 0.707 (95% CI: 0.668, 0.749), while the specificity was 0.851 (95% CI: 0.774, 0.941). Caution is advised in generalizing these findings to other versions of the RT-PCR test that are being used in diverse geographic regions. | |
| 24-04-2020 | |
| Preimpreso | |
| Inglés | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Materiales de Consulta y Comunicados Técnicos |
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| Reconstructed diagnostic sensitivity and specificity of the RT-PCR test for COVID-19.pdf | 603.5 kB | Adobe PDF | Visualizar/Abrir |