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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/8922| Mortality Attributed to COVID-19 in High-Altitude Populations | |
| Orison Woolcott Richard Bergman | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1101/2020.06.10.20128025 | |
| https://www.medrxiv.org/content/10.1101/2020.06.10.20128025v1 | |
| Background Since partial oxygen pressure decreases as altitude increases, environmental hypoxia could worsen COVID-19 patient’s hypoxemia. We compared COVID-19 mortality at different altitudes. Methods Retrospective analysis of population-level data on COVID-19 deaths in the U.S. (1,016 counties) and Mexico (567 municipalities). Mixed-model Poisson regression analysis of the association between altitude and COVID-19 mortality using individual-level data from 40,168 Mexican subjects with COVID-19, adjusting for multiple covariates. Results Between January 20 and April 13, 2020, mortality rates were higher in U.S. counties located at ≥2,000 m elevation vs. those located below 1,500 m (12.3 vs. 3.2 per 100,000; P<0.001). In Mexico, between March 13 and May 13, 2020, mortality rates were higher in municipalities located at ≥2,000 m vs. <1,500 m (5.3 vs. 3.9 per 100,000; P<0.001). Among Mexican subjects <65 years old, the risk of death was 36% higher in those living at ≥2,000 m vs. <1,500 m (adjusted incidence rate ratio: 1.36; 95% CI, 1.05-1.78; P=0.022). Among men, the risk of death was 31% higher at ≥2,000 m vs. <1,500 m (adjusted IRR: 1.31; 95% CI, 1.03-1.66; P=0.025). No association was found among women. Conclusion Altitude is associated with COVID-19 mortality in men younger than 65 years. | |
| bioRxiv | |
| 12-06-2020 | |
| Preimpreso | |
| Inglés | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Materiales de Consulta y Comunicados Técnicos |
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