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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/8883| Estimates of Actual and Potential Lives Saved in the United States from the use of COVID-19 Convalescent Plasma | |
| Quigly Dragotakes david sullivan Rickey Carter Michael Joyner Evan Bloch Kelly Gebo Daniel Hanley Jeffrey Henderson Liise-anne Pirofski Shmuel Shoham Jonathon Senefeld Aaron Tobian Chad Wiggins R. Scott Wright NIgel Paneth Arturo Casadevall | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1101/2024.05.16.24307505 | |
| https://www.medrxiv.org/content/10.1101/2024.05.16.24307505v1 | |
| Abstract In the Spring of 2020, the United States of America (USA) deployed COVID-19 convalescent plasma (CCP) for the treatment of hospitalized patients. Over 500,000 patients were treated with CCP during the first year of the pandemic. In this study, we used CCP weekly use, weekly national mortality data, and CCP mortality reduction data from meta-analyses of randomized controlled trials and real-world data to estimate the number of actual inpatient lives saved by the treatment with CCP in the USA. We also estimate the potential number of lives saved if CCP had been deployed for 100% of hospitalized patients or used in 15% to 75% of outpatients. Depending on the assumptions modeled in stratified analyses, CCP was estimated to have saved between 16,187 and 66,160 lives. The ideal use of CCP might have saved as many as 215,195 lives while preventing 1,136,880 hospitalizations. CCP deployment was a successful strategy for ameliorating the impact of the COVID-19 pandemic in the USA and this experience has important implications for convalescent plasma used in future infectious disease emergencies. | |
| bioRxiv | |
| 18-05-2024 | |
| Preimpreso | |
| Inglés | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Materiales de Consulta y Comunicados Técnicos |
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