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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/8736| Respiratory Failure in Covid19 is associated with increased monocyte expression of complement receptor 3 | |
| Rajeev Gupta vanya gant Bryan Williams Tariq Enver | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1101/2020.05.31.20118638 | |
| https://www.medrxiv.org/content/10.1101/2020.05.31.20118638v1 | |
| A key question in COVID-19 infection is why some previously healthy patients develop severe pulmonary failure and some ultimately die. Initial pulmonary failure does not exhibit classical features of ARDS; hypercoagulability is a common laboratory feature, and pulmonary thrombotic microangiopathy has been reported post mortem1,2,3. Biomarkers cannot robustly identify such patients pre-emptively and no specific interventions exist to mitigate clinical deterioration. Mononuclear phagocytic cells are key immune cells and bind fibrinogen through the CD11b/CD18 dimer CR3, whose activated form can initiate microthrombus formation. Accordingly, we profiled circulating monocyte CD11b/CD18 cell surface density from COVID-19 infected adults who were (i) symptomatic but breathless, (ii) requiring ventilatory support, and (iii) recovering following ICU care for hypoxia. | |
| bioRxiv | |
| 02-06-2020 | |
| Preimpreso | |
| Inglés | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Materiales de Consulta y Comunicados Técnicos |
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| Respiratory Failure in Covid19 is associated with increased monocyte expression of complement receptor 3.pdf | 186.67 kB | Adobe PDF | Visualizar/Abrir |