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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/8705| ACE2 polymorphisms as potential players in COVID-19 outcome | |
| André Salim Khayat paulo assumpcao Bruna Khayat Taíssa Maíra Araújo Jessica Batista-Gomes LUCIANA IMBIRIBA Geraldo Ishak Paula Assumpção Fabiano Moreira Rommel Burbano Andre M Ribeiro-dos-Santos Ândrea Ribeiro_dos_Santos Ney Pereira Carneiro dos Santos Sidney Santos | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1101/2020.05.27.20114843 | |
| https://www.medrxiv.org/content/10.1101/2020.05.27.20114843v1 | |
| The clinical condition COVID-19, caused by SARS-CoV-2, was declared a pandemic by the WHO in March 2020. Currently, there are more than 5 million cases worldwide, and the pandemic has increased exponentially in many countries, with different incidences and death rates among regions/ethnicities and, intriguingly, between sexes. In addition to the many factors that can influence these discrepancies, we suggest a biological aspect, the genetic variation at the viral S protein receptor in human cells, ACE2 (angiotensin I-converting enzyme 2), which may contribute to the worse clinical outcome in males and in some regions worldwide. We performed exomics analysis in native and admixed South American populations, and we also conducted in silico genomics databank investigations in populations from other continents. Interestingly, at least ten polymorphisms in coding, noncoding and regulatory sites were found that can shed light on this issue and offer a plausible biological explanation for these epidemiological differences. In conclusion, ACE2 polymorphisms should influence epidemiological discrepancies observed among ancestry and, moreover, between sexes. | |
| bioRxiv | |
| 29-05-2020 | |
| Preimpreso | |
| Inglés | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Materiales de Consulta y Comunicados Técnicos |
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