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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/8505| SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals | |
| Su Datt Lam Nicola Bordin Harry Scholes Paul Ashford Neeladri Sen Lucy van Dorp Clemens Rauer Natalie L. Willhoft Camilla Pang Mahnaz Abbasian Ian Sillitoe Sarah Edwards Franca Fraternali Jonathan Lees Giovanna Santini Christine Orengo Vaishali Waman | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1101/2020.05.01.072371 | |
| https://www.biorxiv.org/content/10.1101/2020.05.01.072371v6 | |
| SARS-CoV-2 has a zoonotic origin and was transmitted to humans via an undetermined intermediate host, leading to infections in humans and other mammals. To enter host cells, the viral spike protein (S-protein) binds to its receptor, ACE2, and is then processed by TMPRSS2. Whilst receptor binding contributes to the viral host range, S-protein:ACE2 complexes from other animals have not been investigated widely. To predict infection risks, we modelled S-protein:ACE2 complexes from 215 vertebrate species, calculated changes in the energy of the complex caused by mutations in each species, relative to human ACE2, and correlated these changes with COVID-19 infection data. We also analysed structural interactions to better understand the key residues contributing to affinity. We predict that mutations are more detrimental in ACE2 than TMPRSS2. Finally, we demonstrate phylogenetically that human SARS-CoV-2 strains have been isolated in animals. Our results suggest that SARS-CoV-2 can infect a broad range of mammals, but few fish, birds or reptiles. Susceptible animals could serve as reservoirs of the virus, necessitating careful ongoing animal management and surveillance. | |
| bioRxiv | |
| 19-08-2020 | |
| Preimpreso | |
| Inglés | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Materiales de Consulta y Comunicados Técnicos |
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| SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals.pdf | 2.62 MB | Adobe PDF | Visualizar/Abrir |