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Covid-19 Risk by work-related factors: Pooled analysis of individual linked data from 14 cohorts
Matthew Gittins
Jacques Wels
Sarah Rhodes
Bozena Wielgoszewska
Jingmin Zhu
Ellena Badrick
Richard Shaw
Olivia Hamilton
Evangelia Demou
Anna Stevenson
Rebecca Rhead
Srinivasa Katikireddi
George Ploubidis
Martie van Tongeren
Acceso Abierto
Atribución-NoComercial-SinDerivadas
https://doi.org/10.1101/2023.12.19.23298502
https://www.medrxiv.org/content/10.1101/2023.12.19.23298502v1
Background SARS-CoV-2 infection rates vary by occupation, but the association with work-related characteristics (such as home working, key-worker, or furlough) are not fully understood and may depend on ascertainment approach. We assessed infection risks across work-related characteristics and compared findings using different ascertainment approaches. Methods Participants of 14 UK-based longitudinal cohort studies completed surveys before and during the COVID-19 pandemic about their health, work, and behaviour. These data were linked to NHS digital health records, including COVID-19 diagnostic testing, within the UK Longitudinal Linkage Collaboration (UK-LLC) research environment. Poisson regression modelled self-reported infection and diagnostic test confirmed infection within each cohort for work-related characteristics. Risk Ratios (RR) were then combined using random effects meta-analysis. Results Between March 2020 and March 2021, 72,290 individuals completed 167,302 surveys. Overall, 11% of 138,924 responses self-reported an infection, whereas 1.9% of 159,820 responses had a linked positive test. Self-reported infection risk was greater in key-workers vs not (RR=1.24(95%C.I.=1.17,1.31), among non-home working (1.08(0.98,1.19)) or some home working (1.08(0.97,1.17)) vs all home working. Part-time workers vs full-time (0.94(0.89,0.99)), and furlough vs not (0.97(0.88,1.01)) had reduced risk. Results for the linked positive test outcome were comparable in direction but greater in magnitude e.g. an 1.85(1.56,2.20) in key-workers. Conclusion The UK-LLC provides new opportunities for researchers to investigate risk factors, including occupational factors, for ill-health events in multiple largescale UK cohorts. Risk of SARS-CoV-2 infection and COVID-19 illness appeared to be associated with work-related characteristics. Associations using linked diagnostic test data appeared stronger than self-reported infection status.
bioRxiv
19-12-2023
Preimpreso
Inglés
Público en general
VIRUS RESPIRATORIOS
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