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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/8391| COVID-19 is an emergent disease of aging | |
| Didac Santesmasses José Pedro Castro Aleksandr Zenin Anastasia Shindyapina Maxim Gerashchenko Bohan Zhang Csaba Kerepesi Sun Hee Yim peter fedichev Vadim Gladyshev | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1101/2020.04.15.20060095 | |
| https://www.medrxiv.org/content/10.1101/2020.04.15.20060095v1 | |
| COVID-19 is an ongoing pandemic caused by the SARS-CoV-2 coronavirus that poses one of the greatest challenges to public health in recent years. SARS-CoV-2 is highly contagious and often leads to severe viral pneumonia with respiratory failure and death in the elderly and subjects with pre-existing conditions, but the reason for this age dependence is unclear. Here, we found that the case fatality rate for COVID-19 grows exponentially with age in Italy, Spain, South Korea, and China, with the doubling time approaching that of all-cause human mortality. In addition, men and those with multiple age-related diseases are characterized by increased mortality. Moreover, similar mortality patterns were found for all-cause pneumonia. We further report that the gene expression of ACE2, the SARS-CoV-2 receptor, grows in the lung with age, except for subjects on a ventilator. Together, our findings establish COVID-19 as an emergent disease of aging, and age and age-related diseases as its major risk factors. In turn, this suggests that COVID-19, and deadly respiratory diseases in general, may be targeted, in addition to therapeutic approaches that affect specific pathways, by approaches that target the aging process. | |
| bioRxiv | |
| 15-04-2020 | |
| Preimpreso | |
| Inglés | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Materiales de Consulta y Comunicados Técnicos |
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| COVID-19 is an emergent disease of aging.pdf | 266.72 kB | Adobe PDF | Visualizar/Abrir |