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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/8314| Temperature dependence of COVID-19 transmission | |
| Alessio Notari | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1101/2020.03.26.20044529 | |
| https://www.medrxiv.org/content/10.1101/2020.03.26.20044529v3 | |
| The recent coronavirus pandemic follows in its early stages an almost exponential expansion, with the number of cases as a function of time reasonably well fit by N (t) ∝ eαt, in many countries. We analyze the rate α in different countries, choosing as a starting point in each country the first day with 30 cases and fitting for the following 12 days, capturing thus the early exponential growth in a rather homogeneous way. We look for a link between the rate α and the average temperature T of each country, in the month of the epidemic growth. We analyze a base set of 42 countries, which developed the epidemic at an earlier stage, an intermediate set of 88 countries and an extended set of 125 countries, which developed the epidemic more recently. Fitting with a linear behavior α(T), we find increasing evidence in the three datasets for a decreasing growth rate as a function of T, at 99.66%C.L., 99.86%C.L. and 99.99995% C.L. (p-value 5 10−7, or 5σ detection) in the base, intermediate and extended dataset, respectively. The doubling time is expected to increase by 40% 50%, going from 5° C to 25° C. In the base set, going beyond a linear model, a peak at about (7.7 ± 3.6)°C seems to be present in the data, but such evidence disappears for the larger datasets. Moreover we have analyzed the possible existence of a bias: poor countries, typically − located in warm regions, might have less intense testing. By excluding countries below a given GDP per capita from the dataset, we find that this affects our conclusions only slightly and only for the extended dataset. The significance always remains high, with a p-value of about 10−3 10−4 or less. Our findings give hope that, for northern hemisphere countries, the growth rate should significantly decrease as a result of both warmer weather and lockdown policies. In general the propagation should be hopefully stopped by strong lockdown, testing and tracking policies, before the arrival of the next cold season. Competing Interest Statement The authors have declared no competing interest. Funding Statement No external funding was received. Author Declarations All relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript | |
| bioRxiv | |
| 24-04-2020 | |
| Preimpreso | |
| Inglés | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Materiales de Consulta y Comunicados Técnicos |
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| Temperature dependence of COVID-19 transmission.pdf | 597.5 kB | Adobe PDF | Visualizar/Abrir |