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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/8207| Explainable machine learning for the identification of proteome states via the data processing kitchen sink | |
| Malmstroem Lars Aaron Scott Erik Hartman Johan Malmström | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1101/2023.08.30.555506 | |
| https://www.biorxiv.org/content/10.1101/2023.08.30.555506v1 | |
| The application of machine learning algorithms to facilitate the understanding of changes in proteome states has emerged as a promising methodology in proteomics research. Unfortunately, these methods can prove difficult to interpret, as it may not be immediately obvious how models reach their predictions. We present the data processing kitchen sink (DPKS) which provides reproducible access to classic statistical methods and advanced explainable machine learning algorithms to build highly accurate and fully interpretable predictive models. In DPKS, explainable machine learning methods are used to calculate the importance of each protein towards the prediction of a model for a particular proteome state. The calculated importance of each protein can enable the identification of proteins that drive phenotypic change in a data-driven manner while classic techniques rely on arbitrary cutoffs that may exclude important features from consideration. DPKS is a free and open source Python package available at (https://github.com/InfectionMedicineProteomics/DPKS). | |
| bioRxiv | |
| 31-08-2023 | |
| Preimpreso | |
| Inglés | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Materiales de Consulta y Comunicados Técnicos |
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| Fichero | Tamaño | Formato | |
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| Explainable machine learning for the identification of proteome states via the data processing kitchen sink.pdf | 10.47 MB | Adobe PDF | Visualizar/Abrir |