Por favor, use este identificador para citar o enlazar este ítem:
http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/8164| Diversity of Short Linear Interaction Motifs in SARS-CoV-2 Nucleocapsid Protein | |
| Peter Schuck HUAYING ZHAO | |
| Acceso Abierto | |
| Sin Derechos Reservados | |
| https://doi.org/10.1101/2023.08.01.551467 | |
| https://www.biorxiv.org/content/10.1101/2023.08.01.551467v1 | |
| SUMMARY Molecular mimicry of short linear interaction motifs has emerged as a key mechanism for viral proteins binding host domains and hijacking host cell processes. Here, we examine the role of RNA-virus sequence diversity in the dynamics of the virus-host interface, by analyzing the uniquely vast sequence record of viable SARS-CoV-2 species with focus on the multi-functional nucleocapsid protein. We observe the abundant presentation of motifs encoding several essential host protein interactions, alongside a majority of possibly non-functional and randomly occurring motif sequences absent in subsets of viable virus species. A large number of motifs emerge ex nihilo through transient mutations relative to the ancestral consensus sequence. The observed mutational landscape implies an accessible motif space that spans at least 25% of known eukaryotic motifs. This reveals motif mimicry as a highly dynamic process with the capacity to broadly explore host motifs, allowing the virus to rapidly evolve the virus-host interface. | |
| bioRxiv | |
| 01-08-2023 | |
| Preimpreso | |
| Inglés | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Materiales de Consulta y Comunicados Técnicos |
Cargar archivos:
| Fichero | Tamaño | Formato | |
|---|---|---|---|
| Diversity of Short Linear Interaction Motifs in SARS-CoV-2 Nucleocapsid Protein.pdf | 2.48 MB | Adobe PDF | Visualizar/Abrir |