Por favor, use este identificador para citar o enlazar este ítem:
http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/8115| SARS-CoV-2 infection induces dopaminergic neuronal loss in midbrain organoids during short and prolonged cultures | |
| Javier Jarazo Eveline Santos da Silva Enrico Glaab Danielle Perez Bercoff Jens Schwamborn | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1101/2023.03.20.533485 | |
| https://www.biorxiv.org/content/10.1101/2023.03.20.533485v1 | |
| Abstract COVID-19 is mainly associated with respiratory symptoms, although several reports showed that SARS-CoV-2 affects the nervous system. We evaluated the effects of infection in prolonged culture of midbrain organoids, showing that the virus induces changes in gene expression, and fragmentation and loss of dopaminergic neurons. Our findings highlight the direct viral-induced damage to midbrain organoids indicating the relevance of assessing the neurological long-term evolution of COVID-19 patients. | |
| bioRxiv | |
| 21-03-2023 | |
| Preimpreso | |
| Inglés | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Materiales de Consulta y Comunicados Técnicos |
Cargar archivos:
| Fichero | Tamaño | Formato | |
|---|---|---|---|
| SARS-CoV-2 infection induces dopaminergic neuronal loss in midbrain organoids during short and prolonged cultures.pdf | 15.07 MB | Adobe PDF | Visualizar/Abrir |