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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/8103| Community structure and temporal dynamics of SARS-CoV-2 epistatic network allows for early detection of emerging variants with altered phenotypes | |
| Fatemeh Mohebbi Gerardo Chowell Alexander Zelikovsky Serghei Mangul Pavel Skums | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1101/2023.04.02.535277 | |
| https://www.biorxiv.org/content/10.1101/2023.04.02.535277v1 | |
| Abstract The rise of viral variants with altered phenotypes presents a significant public health challenge. In particular, the successive waves of COVID-19 have been driven by emerging variants of interest (VOIs) and variants of concern (VOCs), which are linked to modifications in phenotypic traits such as transmissibility, antibody resistance, and immune escape. Consequently, devising effective strategies to forecast emerging viral variants is critical for managing present and future epidemics. Although current evolutionary prediction tools mainly concentrate on single amino acid variants (SAVs) or isolated genomic changes, the observed history of VOCs and the extensive epistatic interactions within the SARS-CoV-2 genome suggest that predicting viral haplotypes, rather than individual mutations, is vital for efficient genomic surveillance. However, haplotype prediction is significantly more challenging problem, which precludes the use of traditional AI and Machine Learning approaches utilized in most mutation-based studies. This study demonstrates that by examining the community structure of SARS-CoV-2 spike protein epistatic networks, it is feasible to efficiently detect or predict emerging haplotypes with altered transmissibility. These haplotypes can be linked to dense network communities, which become discernible significantly earlier than their associated viral variants reach noticeable prevalence levels. From these insights, we developed HELEN (Heralding Emerging Lineages in Epistatic Networks), a computational framework that identifies densely epistatically connected communities of SAV alleles and merges them into haplotypes using a combination of statistical inference, population genetics, and discrete optimization techniques. HELEN was validated by accurately identifying known SARS-CoV-2 VOCs and VOIs up to 10-12 months before they reached perceptible prevalence and were designated by the WHO. For example, our approach suggests that the spread of the Omicron haplotype or a closely related genomic variant could have been foreseen as early as the start of 2021, almost a year before its WHO designation. Moreover, HELEN offers greater scalability than phylogenetic lineage tracing methods, allowing for the analysis of millions of available SARS-CoV-2 genomes. Besides SARS-CoV-2, our methodology can be employed to detect emerging and circulating strains of any highly mutable pathogen with adequate genomic surveillance data. | |
| bioRxiv | |
| 03-04-2023 | |
| Preimpreso | |
| Inglés | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Materiales de Consulta y Comunicados Técnicos |
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