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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/8094| Single-cycle SARS-CoV-2 vaccine elicits high protection and sterilizing immunity in hamsters | |
| Vladimir Cmiljanovic Fabian Otte Claudia Wylezich Lorena Urda Christopher Lang Martin Beer Christian Mittelholzer Thomas Klimkait Martin Joseph LETT David Hauser Jacob Schön Enja Tatjana Kipfer Donata Hoffmann Nico Joel Halwe Lorenz Ulrich Yuepeng Zhang | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1101/2023.05.17.541127 | |
| Abstract Vaccines have been central in ending the COVID-19 pandemic, but newly emerging SARS-CoV-2 variants increasingly escape first-generation vaccine protection. To fill this gap, live particle-based vaccines mimicking natural infection aim at protecting against a broader spectrum of virus variants. We designed “single-cycle SARS-CoV-2 viruses” (SCVs) that lack essential viral genes, possess superior immune-modulatory features and provide an excellent safety profile in the Syrian hamster model. Full protection of all intranasally vaccinated animals was achieved against an autologous challenge with SARS-CoV-2 virus using an Envelope-gene-deleted vaccine candidate. By deleting key immune-downregulating genes, sterilizing immunity was achieved with an advanced candidate without virus spread to contact animals. Hence, SCVs have the potential to induce a broad and durable protection against COVID-19 superior to a natural infection. | |
| bioRxiv | |
| 17-05-2023 | |
| Preimpreso | |
| Inglés | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Materiales de Consulta y Comunicados Técnicos |
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| Single-cycle SARS-CoV-2 vaccine elicits high protection and sterilizing immunity in hamsters.pdf | 2.98 MB | Adobe PDF | Visualizar/Abrir |