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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/8093| Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2 | |
| Leela Shrestha David Speedman Huanyu Li Ashley Pike Gamma Chi Jesper Soendergaard Hansen Sarah Lee Karin Rodstrom Simon Bushell Adam Evans Dong Wang Didi He Chady Nasrallah Nicola Burgess_Brown Tim Dafforn Liz Carpenter David Sauer | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1101/2023.05.17.541173 | |
| https://www.biorxiv.org/content/10.1101/2023.05.17.541173v1 | |
| Abstract Proline is widely known as the only proteogenic amino acid with a secondary amine. In addition to its crucial role in protein structure, the secondary amino acid modulates neurotransmission and regulates the kinetics of signaling proteins. To understand the structural basis of proline import, we solved the structure of the proline transporter SIT1 in complex with the COVID-19 viral receptor ACE2 by cryo-electron microscopy. The structure of pipecolate-bound SIT1 reveals the specific sequence requirements for proline transport in the SLC6 family and how this protein excludes amino acids with extended side chains. By comparing apo and substrate-bound SIT1 states, we also identify the structural changes which link substrate release and opening of the cytoplasmic gate, and provide an explanation for how a missense mutation in the transporter causes iminoglycinuria. | |
| bioRxiv | |
| 18-05-2023 | |
| Preimpreso | |
| Inglés | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Materiales de Consulta y Comunicados Técnicos |
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|---|---|---|---|
| Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.pdf | 2.91 MB | Adobe PDF | Visualizar/Abrir |