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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/8085| Risk of new-onset Long Covid following reinfection with SARS-CoV-2: community-based cohort study | |
| Boran Shenhuy Matthew Bosworth Ann Sarah Walker Vahé Nafilyan Nisreen Alwan Margaret O'Hara Daniel Ayoubkhani | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1101/2023.04.13.23288522 | |
| https://www.medrxiv.org/content/10.1101/2023.04.13.23288522v1 | |
| Abstract Background Little is known about the risk of Long Covid following reinfection with SARS-CoV-2. We estimated the likelihood of new-onset, self-reported Long Covid after a second SARS-CoV-2 infection, and compared to a first infection. Methods We included UK COVID-19 Infection Survey participants who tested positive for SARS-CoV-2 between 1 November 2021 and 8 October 2022. The primary outcome was self-reported Long Covid 12 to 20 weeks after each infection. Separate analyses were performed for those <16 years and ≥16 years. We estimated adjusted odds ratios (aORs) for new-onset Long Covid using logistic regression, comparing second to first infections, controlling for socio-demographic characteristics and calendar date of infection, plus vaccination status in those ≥16 years. Results Overall, Long Covid was reported by those ≥16 years after 4.0% and 2.4% of first and second infections, respectively; the corresponding estimates among those <16 years were 1.0% and 0.6%. The aOR for Long Covid after second compared to first infections was 0.72 (95% confidence interval: 0.63–0.81) for those ≥16 years and 0.93 (0.57–1.53) for those <16 years. Conclusions The risk of new-onset Long Covid after a second SARS-CoV-2 infection is lower than that after a first infection for those ≥16 years, though there is no evidence of a difference in risk for those <16 years. However, there remains some risk of new-onset Long Covid after a second infection, with around 1 in 40 of those ≥16 years and 1 in 165 of those <16 years reporting Long Covid after a second infection. Competing Interest Statement All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and declare: no support from any organisation for the submitted work; and no financial relationships with any organisations that might have an interest in the submitted work in the previous three years. MEO has received Patient Involvement honorarium for speaking at a Long Covid Physio International Forum panel discussion. NAA is a co-investigator on the NIHR-supported research on Long Covid (STIMULATE-ICP and HI-COVE studies), a Long Covid Kids Charity Champion, a Long Covid Support Charity Advisor, and has contributed in an advisory capacity to WHO and EU Commission's Expert Panel on effective ways of investing in health meetings in relation to post-COVID-19 condition. | |
| bioRxiv | |
| 17-04-2023 | |
| Preimpreso | |
| Inglés | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Materiales de Consulta y Comunicados Técnicos |
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