Por favor, use este identificador para citar o enlazar este ítem:
http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/8044| Non-COVID-19 mortality in France, April 2020 - June 2022: reduction compared to pre-pandemic mortality patterns, relative increase during the Omicron period, and the importance of detecting SARS-CoV-2 infections | |
| Edward Goldstein | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1101/2022.11.28.22282832 | |
| https://www.medrxiv.org/content/10.1101/2022.11.28.22282832v1 | |
| Abstract Aims We compared the number of non-COVID-19 deaths between April 2020 and June 2022 to the expected number of deaths based on the patterns observed in the five years prior to the pandemic in France with the aims of (a) estimating the reduction in non-COVID-19 mortality, particularly due to reduction in the circulation of other respiratory viruses during the pandemic; (b) examining the degree to which SARS-CoV-2 infection was detected and characterized as a cause of death during different periods of the pandemic. Methods Using a previously developed regression model, we expressed weekly mortality rates in the 5-year period prior to the pandemic as a combination of influenza-associated mortality rates and baseline and a linear trend for the rates of non-influenza mortality. Estimates for the baseline and trend for non-influenza mortality together with estimates of influenza-related mortality prior to the pandemic were used to estimate expected mortality during the pandemic period. Results The number of recorded non-COVID-19 deaths between week 15, 2020 and week 26, 2022 in France was less than the expected number of deaths by 49,623 (95% CI (20364,78837)). Additionally, rates of non-COVID-19 mortality increased during the later part of the study period, with the difference between the number of non-COVID-19 deaths and the expected number of deaths during the last 52 weeks of the study period being greater than the corresponding difference for the first 52 weeks of the study period by 28,954 (24979,32918) deaths. Conclusions Our results suggest (a) the effectiveness of mitigation measures during the pandemic for reducing the rates of non-COVID-19 mortality, particularly mortality related to circulation of other respiratory viruses, including influenza (that was responsible for an annual average of 15,334 (12593,18077) deaths between 2015-2019 in France); (b) detection of a high proportion of SARS-CoV-2 infections leading to deaths in France, and characterization of those infections as the underlying cause of death. Additionally, while the increase in non-COVID-19 mortality during the later part of the study period is partly related to the temporal increase in the circulation of other respiratory viruses, there was an increase, particularly during the period of the circulation of the Omicron variant, in the proportion of hospitalizations with a SARS-CoV-2 infection in France that were coded as hospitalizations with COVID-19 (rather than COVID-19 ho | |
| bioRxiv | |
| 29-11-2022 | |
| Preimpreso | |
| Inglés | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Materiales de Consulta y Comunicados Técnicos |
Cargar archivos:
| Fichero | Tamaño | Formato | |
|---|---|---|---|
| Non-COVID-19 mortality in France, April 2020 - June 2022.pdf | 547.02 kB | Adobe PDF | Visualizar/Abrir |