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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/8020| COVID-19 and silent hypoxemia in a minimal closed-loop model of the respiratory rhythm generator | |
| Casey Diekman Peter Thomas Christopher Wilson | |
| Acceso Abierto | |
| Atribución-NoComercial | |
| https://doi.org/10.1101/2023.04.19.536507 | |
| https://www.biorxiv.org/content/10.1101/2023.04.19.536507v1 | |
| Silent hypoxemia, or `happy hypoxia', is a puzzling phenomenon in which patients who have contracted COVID-19 exhibit very low oxygen saturation (SaO280%) but do not experience discomfort in breathing. The mechanism by which this blunted response to hypoxia occurs is unknown. We have previously shown that a computational model (Diekman et al., 2017, J. Neurophysiol) of the respiratory neural network can be used to test hypotheses focused on changes in chemosensory inputs to the central pattern generator (CPG). We hypothesize that altered chemosensory function at the level of the carotid bodies and/or the nucleus tractus solitarii are responsible for the blunted response to hypoxia. Here, we use our model to explore this hypothesis by altering the properties of the gain function representing oxygen sensing inputs to the CPG. We then vary other parameters in the model and show that oxygen carrying capacity is the most salient factor for producing silent hypoxemia. We call for clinicians to measure hematocrit as a clinical index of altered physiology in response to COVID-19 infection. | |
| bioRxiv | |
| 19-04-2022 | |
| Preimpreso | |
| https://www.biorxiv.org/ | |
| Inglés | |
| Epidemia COVID-19 | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Materiales de Consulta y Comunicados Técnicos |
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| Covid 19 and silent hypoxemia in a minimal closed.pdf | 1.68 MB | Adobe PDF | Visualizar/Abrir |