Por favor, use este identificador para citar o enlazar este ítem:
http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/7584| ATP6V1B2 and IFI27 and their intrinsic functional genomic characteristics associated with SARS-CoV-2 | |
| Zhengjun Zhang | |
| Acceso Abierto | |
| Atribución-NoComercial | |
| https://doi.org/10.1101/2022.01.13.476223 | |
| https://www.biorxiv.org/content/10.1101/2022.01.13.476223v1 | |
| Genes functionally associated with SARS-CoV-2 and genes functionally related to COVID-19 disease can be different, whose distinction will become the first essential step for successfully fighting against the COVID-19 pandemic. Unfortunately, this first step has not been completed in all biological and medical research. Using a newly developed max-competing logistic classifier, two genes, ATP6V1B2 and IFI27, stand out to be critical in transcriptional response to SARS-CoV-2 with differential expressions derived from NP/OP swab PCR. This finding is evidenced by combining these two genes with one another gene in predicting disease status to achieve better-indicating power than existing classifiers with the same number of genes. In addition, combining these two genes with three other genes to form a five-gene classifier outperforms existing classifiers with ten or more genes. With their exceptional predicting power, these two genes can be critical in fighting against the COVID-19 pandemic as a new focus and direction. Comparing the functional effects of these genes with a five-gene classifier with 100% accuracy identified and tested from blood samples in the literature, genes and their transcriptional response and functional effects to SARS-CoV-2 and genes and their functional signature patterns to COVID-19 antibody are significantly different, which can be interpreted as the former is the point of a phenomenon, and the latter is the essence of the disease. Such significant findings can help explore the causal and pathological clue between SARS-CoV-2 and COVID-19 disease and fight against the disease with more targeted vaccines, antiviral drugs, and therapies. | |
| medRxiv and bioRxiv | |
| 14-01-2022 | |
| Preimpreso | |
| www.biorxiv.org | |
| Inglés | |
| Epidemia COVID-19 | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos científicos |
Cargar archivos:
| Fichero | Tamaño | Formato | |
|---|---|---|---|
| ATP6V1B2 AND IFI27 and their instrinsic functional genomic characteristics associated with SARS COV2.pdf | 529.51 kB | Adobe PDF | Visualizar/Abrir |