Por favor, use este identificador para citar o enlazar este ítem:
http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/469| Common health conditions in childhood and adolescence, school absence, and educational attainment: Mendelian randomization study | |
| Amanda Hughes Neil M Davies Matt Dickson Alisha Davies Frances Rice Laura Howe Kaitlin H Wade | |
| Novel Coronavirus | |
| Acceso Abierto | |
| Atribución | |
| 10.1101/19012906 | |
| Objectives: To assess the causal relationship of different health conditions in childhood and adolescence with educational attainment and school absence. Design: Longitudinal observational study and Mendelian randomization (MR) analyses. Setting: Avon Longitudinal Study of Parents and Children (ALSPAC), a population sample of children from South-West England born in 1991-1992. Participants: 6113 unrelated children with available GCSE records and genetic data (50% female). Exposures: Six common health conditions with known genetic markers measured at age 10 (primary school) and 13 (mid-secondary school). These were: symptoms of Attention-Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), depression, asthma, migraines and BMI. Genetic liability for these conditions and BMI was indexed by polygenic scores. Main outcome measures: Educational attainment at age 16 (total GCSE and equivalents points score), school absence at age 14-16. Results: In multivariate-adjusted observational models, all health conditions except asthma and migraines were associated with poorer educational attainment and greater school absence. Substantial mediation by school absence was seen for BMI (e.g. 35.6% for BMI at 13) and migraines (67% at age 10), with more modest mediation for behavioural and neurodevelopmental measures of health. In genetic models, a unit increase in genetically instrumented BMI z-score at age 10 predicted a 0.19 S.D. decrease (95% CI: -0.28 to -0.11) in attainment at 16, equivalent to around a 1/3 grade difference in each subject. It also predicted 8.6% more school absence (95% CI:1.3%, 16.5%). Similar associations were seen for BMI at age 13. Consistent with previous work, genetic liability for ADHD predicted lower educational attainment, but did not clearly increase school absence. Conclusions: Triangulation across multiple approaches supported a causal, negative influence of higher BMI on educational attainment and school absence. Further research is required to understand the mechanisms linking higher BMI with school absence and attainment. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This research was specifically funded by the Health Foundation. The Medical Research Council (MRC) and the University of Bristol support the MRC Integrative Epidemiology Unit [MC_UU_12013/1, MC_UU_12013/9, MC_UU_00011/1]. The Economics and Social Research Council (ESRC) support NMD via a Future Research Leaders grant [ES/N000757/1]. LDH is supported by a Career Development Award from the UK Medical Research Council (MR/M020894/1). KHW is supported by the Elizabeth Blackwell Institute for Health Research, University of Bristol and the Wellcome Trust Institutional Strategic Support Fund [204813/Z/16/Z]. This work is part of a project entitled Social and economic consequences of health: causal inference methods and longitudinal, intergenerational data, which is part of the Health Foundations Efficiency Research Programme. The Health Foundation is an independent charity committed to bringing about better health and health care for people in the UK. No funding body has influenced data collection, analysis or its interpretation. This publication is the work of the authors, who serve as the guarantors for the contents of this paper ### Author Declarations All relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript. Yes All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes The data concerns individual human subjects and therefore is not freely available, but can be obtained by researchers by applying to ALSPAC. | |
| Cold Spring Harbor Laboratory Press | |
| 2019 | |
| Preimpreso | |
| https://www.medrxiv.org/content/10.1101/19012906v1 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
Cargar archivos:
| Fichero | Tamaño | Formato | |
|---|---|---|---|
| Common health conditions.pdf | 575.11 kB | Adobe PDF | Visualizar/Abrir |