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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/3649| A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease | |
| Hall Donald C. Ji Hai-Feng. | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1016/j.tmaid.2020.101646 | |
| BACKGROUND:The COVID-19 has now been declared a global emergency by the World Health Organization. There is an emergent need to search for possible medications. METHOD:Utilization of the available sequence information, homology modeling, and in slico docking a number of available medications might prove to be effective in inhibiting the COVID-19 two main drug targets the spike glycoprotein and the 3CL protease. RESULTS:Several compounds were determined from the in silico docking models that might prove to be effective inhibitor for the COVID-19. Several antiviral medications: Zanamivir, Indinavir, Saquinavir, and Remdesivir show potential as and 3CLPRO main proteinase inhibitors and as a treatment of COVID-19. CONCLUSION:Zanamivir, Indinavir, Saquinavir, and Remdesivir are among the exciting hits on the 3CLPRO main proteinase. It is also exciting to uncover that Flavin Adenine Dinucleotide (FAD) Adeflavin, B2 Deficiency medicine, and Coenzyme A, a coenzyme, may also be potentially used for the treatment of SARS-CoV-2 infections. The use of these off-label medications may be beneficial in the treatment of the COVID-19. | |
| Travel Medicine and Infectious Disease | |
| 2020 | |
| Artículo | |
| https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152904/pdf/main.pdf | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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