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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/3640| Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan | |
| Li Xiaochen. Xu Shuyun. Yu Muqing. Wang Ke. Tao Yu. Zhou Ying. Shi Jing. Zhou Min. Wu Bo. Yang Zhenyu. Zhang Cong. Yue Junqing. Zhang Zhiguo. Renz Harald. Liu Xiansheng. Xie Jungang. Xie Min. Zhao Jianping. | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1016/j.jaci.2020.04.006 | |
| BACKGROUND:In December 2019, COVID-19 outbreak occurred in Wuhan. Data on the clinical characteristics and outcomes of patients with severe COVID-19 are limited. OBJECTIVE:The severity on admission, complications, treatment, and outcomes of COVID-19 patients were evaluated. METHODS:Patients with COVID-19 admitted to Tongji Hospital from January 26, 2020 to February 5, 2020 were retrospectively enrolled and followed-up until March 3, 2020. Potential risk factors for severe COVID-19 were analyzed by a multivariable binary logistic model. Cox proportional hazard regression model was used for survival analysis in severe patients. RESULTS:We identified 269 (49.1%) of 548 patients as severe cases on admission. Elder age, underlying hypertension, high cytokine levels (IL-2R, IL-6, IL-10, and TNF-a), and high LDH level were significantly associated with severe COVID-19 on admission. The prevalence of asthma in COVID-19 patients was 0.9%, markedly lower than that in the adult population of Wuhan. The estimated mortality was 1.1% in nonsevere patients and 32.5% in severe cases during the average 32 days of follow-up period. Survival analysis revealed that male, elder age, leukocytosis, high LDH level, cardiac injury, hyperglycemia, and high-dose corticosteroid use were associated with death in patients with severe COVID-19. CONCLUSIONS:Patients with elder age, hypertension, and high LDH level need careful observation and early intervention to prevent the potential development of severe COVID-19. Severe male patients with heart injury, hyperglycemia, and high-dose corticosteroid use may have high risk of death. | |
| Journal of Allergy and Clinical Immunology | |
| 2020 | |
| Artículo | |
| https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152876/pdf/main.pdf | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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