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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/324| Estimates of the global burden of Japanese Encephalitis and the impact of vaccination from 2000-2015 | |
| Tran Minh Nhat Nguyen Manh Duy Tran Thi Nhu Thao Tran Minh Quan Hannah Clapham | |
| Novel Coronavirus | |
| Acceso Abierto | |
| Atribución | |
| 10.1101/19006940 | |
| Japanese encephalitis (JE) is a mosquito-borne disease, known for its high death and disability rate among symptomatic cases. Many effective vaccines are available for JE, and the use of a recently developed and inexpensive vaccine has been increasing over the recent years particularly with Gavi support. Estimates of the local burden and the past impact of vaccination are therefore increasingly needed, but difficult due to the limitations of JE surveillance. In this study, we implemented a mathematical modelling method combined with age-stratifed case data which can overcome some of these limitations. We estimate in 2015 JE infections caused 100,308 cases (95%CI: 61,720 - 157,522) and 25,125 deaths (95%CI: 14,550 - 46,031), and that between 2000 and 2015 307,774 JE cases (95%CI: 167,442- 509,583) were averted due to vaccination. Our results highlight areas that could have the greatest benefit from starting vaccination or from scaling up existing programs and will be of use to support local and international policymakers in making vaccine allocation decisions. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This work was funded by the Vaccine Impact Modelling Consortium (https://www.vaccineimpact.org/, Bill and Melinda Gates Foundation & Gavi): Tran Minh Quan, Tran Thi Nhu Thao, Nguyen Manh Duy, Tran Minh Nhat, Wellcome Trust: Hannah Clapham, 089276/B/09/7 The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. ### Author Declarations All relevant ethical guidelines have been followed and any necessary IRB and/or ethics committee approvals have been obtained. Yes All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Not Applicable Any clinical trials involved have been registered with an ICMJE-approved registry such as ClinicalTrials.gov and the trial ID is included in the manuscript. Not Applicable I have followed all appropriate research reporting guidelines and uploaded the relevant Equator, ICMJE or other checklist(s) as supplementary files, if applicable. Yes This study conducted a literature review and collated all data on age-stratified JE cases from these papers. The full list of these papers and the data extracted is available in the supplement. | |
| Cold Spring Harbor Laboratory Press | |
| 2019 | |
| Preimpreso | |
| https://www.medrxiv.org/content/10.1101/19006940v1 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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| Fichero | Tamaño | Formato | |
|---|---|---|---|
| Estimates of the global burden.pdf | 683.05 kB | Adobe PDF | Visualizar/Abrir |