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|Lack of Antiviral Activity of Darunavir against SARS-CoV-2|
|Sandra De Meyer.|
Ellen Van Damme.
Marnix Van Loock.
|Given the high need and the absence of specific antivirals for treatment of COVID-19 (the disease caused by severe acute respiratory syndrome-associated coronavirus-2 [SARS-CoV-2]), human immunodeficiency virus (HIV) protease inhibitors are being considered as therapeutic alternatives. Prezcobix/Rezolsta is a fixed-dose combination of 800 mg of the HIV protease inhibitor darunavir (DRV) and 150 mg cobicistat, a CYP3A4 inhibitor, which is indicated in combination with other antiretroviral agents for the treatment of HIV infection. There are currently no definitive data on the safety and efficacy of DRV/cobicistat for treatment of COVID-19. The in vitro antiviral activity of darunavir against a clinical isolate from a patient infected with SARS-CoV-2 was assessed. DRV showed no activity against SARS-CoV-2 at clinically relevant concentrations (EC50 >100 M). Remdesivir, used as a positive control, showed potent antiviral activity (EC50 = 0.38 M). Overall, the data do not support the use of DRV for treatment of COVID-19.|
|Appears in Collections:||Artículos científicos|