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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/942| The GReek study in the Effects of Colchicine in COvid-19 complications prevention (GRECCO-19 study): rationale and study design | |
| Deftereos, S Siasos, G Giannopoulos, G Vrachatis, D Angelidis, C Giotaki, S Gargalianos, P Giamarellou, H Gogos, C Daikos, G Lazanas, M Lagiou, P Saroglou, G Sipsas, N Tsiodras, S Chatzigeorgiou, D Moussas, N Kotanidou, A Koulouris, N Oikonomou, E Kaoukis, A Kossyvakis, C Raisakis, K Fountoulaki, K Comis, M Tsiachris, D Sarri, E Theodorakis, A Martinez-Dolz, L Jorge, S Reimers, B Stefanini, G Cleman, M Filippou, D Olympios, C Pyrgakis, V Goudevenos, J Hahalis, G Kolettis, T Iliodromitis, E Tousoulis, D Stefanadis, C | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| Background Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. Methods GRECCO-19 will be prospective, cluster randomized, open-labeled, controlled study. Patients with laboratory confirmed SARS-CoV-2 infection (under RT PCR) and clinical picture that involves temperature >37.5 oC and at least two out of the: i. sustained coughing, ii. sustained throat pain, iii. Anosmia and/or ageusia, iv. fatigue/tiredness, v. PaO2<95 mmHg will be included. Conclusions GRECCO-19 trial aims to identify whether colchicine may positively intervene in the clinical course of COVID-19. (The study has been submitted to clinicaltrials.gov on March 26, 2020) | |
| Hellenic Journal of Cardiology - HJC | |
| 2020 | |
| Preimpreso | |
| https://coronavirus.1science.com/item/263e29c96b813beff006e46039460c533bd5a465 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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