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Disability-Adjusted Life-Years (DALYs) for Breast Cancer and Risk Factors in 195 countries: Findings from Global Burden of Disease Study 2017
Jieyu Liu
Jiaxiang Wang
Novel Coronavirus
Acceso Abierto
Atribución-NoComercial-SinDerivadas
10.1101/2020.04.02.20050534
Background: Breast cancer is a leading cancer burden for females. In order to picture the patterns and time trends of the breast cancer burden across different regions, the disability adjusted life years (DALYs) were used to estimate breast cancer burden from 1990 to 2017. Methods: Data from Global Burden of Disease Study 2017 (GBD 2017) was used to estimate the disability adjusted life years (DALYs) for the burden of breast cancer by locations, regions, years (with corresponding 95% uncertainty intervals [UI]). Besides, the associated potentially modifiable risk factors were estimated to provide targeted means for controlling the burden of breast cancer. Results: All age numbers of DALYs reached over 17.42 million years in 2017 globally, despite the decreasing trends in all age and age standardized rate. The rates for DALYs was the highest in Western SubSaharan Africa [694.23 (534.43 to 906.05)] in 2017. High fasting plasma glucose [1.07 million (0.20 to 2.43) DALYs] and high body mass index (BMI) [0.81 million (0.27 to 1.53) DALYs] have become great attributors to DALYs of breast cancer in 2017. Conclusions: The levels and trends in causes of DALYs of breast cancer, generally show similiarities between 2007 and 2017, although differences exist. The differences observed countries can be attributed high fasting plasma glucose and high body mass index across the world. Concerned efforts at national and regional levels are required to tackle the emerging burden of breast cancer in the world. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement No FUNDING ### Author Declarations All relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript. Yes All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes All data are available online
Cold Spring Harbor Laboratory Press
2020
Preimpreso
https://www.medrxiv.org/content/10.1101/2020.04.02.20050534v1
Inglés
VIRUS RESPIRATORIOS
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