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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/7951| Effectiveness of a multidrug therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico | |
| RENE LIMA MORALES PABLO MENDEZ HERNANDEZ PATRICIA OSORNO ROMERO CHRISTIAN RONAL SANCHO HERNÁNDEZ ELIZABETH CUECUECHA RUGERIO ADRIÁN NAVA ZAMORA DIEGO ROLANDO HERNANDEZ GALDAMEZ DANIELA KAROLA ROMO DUEÑAS Jorge Salmerón | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1016/j.ijid.2021.02.014 | |
| Objective: There is an urgent need for effective treatments to prevent or attenuate lung and systemic inflammation, endotheliitis, and thrombosis related to COVID-19. This study aimed to assess the effectiveness of a multidrug-therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid ("TNR4" therapy) to prevent hospitalization and death among ambulatory COVID- 19 cases in Tlaxcala, Mexico. Design and methods: A comparative effectiveness study was performed among 768 confirmed SARS-CoV- 2 cases aged 18–80 years, who received ambulatory care at the Ministry of Health of Tlaxcala. A total of 481 cases received the TNR4 therapy, while 287 received another treatment (comparison group). All participants received home visits and/or phone calls for clinical evaluation during the 14 days after enrollment. Results: Nearly 85% of cases who received the TNR4 recovered within 14 days compared to 59% in the comparison group. The likelihood of recovery within 14 days was 3.4 times greater among the TNR4 group than in the comparison group. Patients treated with TNR4 had a 75% and 81% lower risk of being hospitalized or death, respectively, than the comparison group. Conclusions: TNR4 therapy improved recovery and prevented the risk of hospitalization and death among ambulatory COVID-19 cases. | |
| International Journal of Infectious Diseases | |
| 04-02-2021 | |
| Artículo | |
| https://www.ijidonline.com/ | |
| Inglés | |
| Effectiveness of a multidrug therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico. Lima-Morales, René et al. International Journal of Infectious Diseases, Volume 105, 598 - 605 | |
| VIRUS RESPIRATORIOS | |
| Versión aceptada | |
| acceptedVersion - Versión aceptada | |
| Aparece en las colecciones: | Artículos científicos |
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