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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/7915| Lactate-dehydrogenase associated with mortality in hospitalized patients with COVID-19 in Mexico: a multi-centre retrospective cohort study | |
| PAULINA VIDAL CEBALLOS Fatima Higuera-De La Tijera Norberto Chavez_Tapia Francisco Sanchez Giron EIRA CERDA REYES VÍCTOR HUGO ROSALES SALYANO Alfredo Servín-Caamaño Martín Uriel Vázquez-Medina NAHUM MENDEZ-SANCHEZ | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1016/j.aohep.2021.100338 | |
| Introduction and Objectives: As of January 2021, over 88 million people have been infected with COVID-19. Almost two million people have died of severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2). A high SOFA score and a D-Dimer >1 g/mL identifies patients with high risk of mortality. High lactate dehydrogenase (LDH) levels on admission are associated with severity and mortality. Different degrees of alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) abnormalities have been reported in these patients, its association with a mortality risk remains controversial. The aim of this study was to explore the correlation between LDH and in-hospital mortality in Mexican patients admitted with COVID-19. Materials & Methods: We performed a retrospective multi-centre cohort study with 377 hospitalized patients with confirmed SARS-CoV-2 in three centres in Mexico City, Mexico, who were ≥18 years old and died or were discharged between April 1 and May 31, 2020. Results: A total of 377 patients were evaluated, 298 (79.1%) patients were discharged, and 79 (20.9%) patients died during hospitalization. Non-survivors were older, with a median age of 46.7 ± 25.7 years old, most patients were male. An ALT > 61 U/l (OR 3.45, 95% CI 1.27−9.37; p = 0.015), C-reactive protein (CRP) > 231 mg/l (OR 4.71, 95% CI 2.35−9.46; p = 0.000), LDH > 561 U/l (OR 3.03, 95% CI 1.40−6.55; p = 0.005) were associated with higher odds for in-hospital death. | |
| Annals of Hepatology | |
| 26-02-2021 | |
| Artículo | |
| https://www.sciencedirect.com/ | |
| Inglés | |
| Paulina Vidal-Cevallos, Fatima Higuera-De-La-Tijera, Norberto C. Chávez-Tapia, Francisco Sanchez-Giron, Eira Cerda-Reyes, Victor Hugo Rosales-Salyano, Alfredo Servin-Caamaño, Martín Uriel Vázquez-Medina, Nahum Méndez-Sánchez, Lactate-dehydrogenase associated with mortality in hospitalized patients with COVID-19 in Mexico: a multi-centre retrospective cohort study, Annals of Hepatology, Volume 24, 2021, 100338, ISSN 1665-2681, https://doi.org/10.1016/j.aohep.2021.100338. (https://www.sciencedirect.com/science/article/pii/S1665268121000375) | |
| VIRUS RESPIRATORIOS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos científicos |
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