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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/7910| Prevalence of SARS-CoV-2 Variants of Concern and Variants of Interest in COVID-19 Breakthrough Infections in a Hospital in Monterrey, Mexico | |
| Kame Galán-Huerta Daniel Salas Treviño Paola Bocanegra-Ibarias Eduardo Perez-Alba Ana Maria Rivas-Estilla SONIA AMELIA LOZANO SEPULVEDA DANIEL ARELLANOS SOTO ADRIAN CAMACHO ORTIZ | |
| Acceso Abierto | |
| Atribución | |
| https://doi.org/10.3390/v14010154 | |
| SARS-CoV-2 variants of concern (VOCs) or of interest (VOIs) causing vaccine breakthrough infections pose an increased risk to worldwide public health. An observational case-control study was performed of SARS-CoV-2 vaccine breakthrough infections in hospitalized or ambulatory patients in Monterrey, Mexico, from April through August 2021. Vaccination breakthrough was defined as a SARS-CoV-2 infection that occurred any time after 7 days of inoculation with partial (e.g., first dose of two-dose vaccines) or complete immunization (e.g., second dose of two-dose vaccines or single-dose vaccine, accordingly). Case group patients (n = 53) had partial or complete vaccination schemes with CanSino (45%), Sinovac (19%), Pfizer/BioNTech (15%), and AstraZeneca/Oxford (15%). CanSino was administered most frequently in ambulatory patients (p < 0.01). The control group (n = 19) received no COVID-19 vaccines. Among SARS-CoV-2 variants detected by whole-genome sequencing, VOC Delta B.1.617.2 predominated in vaccinated ambulatory patients (p < 0.01) and AY.4 in hospitalized patients (p = 0.04); VOI Mu B.1.621 was detected in four (7.55%) vaccinated patients. SARS-CoV-2 breakthrough infections in our hospital occurred mostly in patients vaccinated with CanSino due to the higher prevalence of CanSino vaccine administration in our population. These patients developed mild COVID-19 symptoms not requiring hospitalization. The significance of this study lies on the detection of SARS-CoV-2 variants compromising the efficacy of local immunization therapies in Monterrey, Mexico. | |
| Viruses | |
| 14-01-2022 | |
| Artículo | |
| https://www.mdpi.com/ | |
| Inglés | |
| Galán-Huerta, K.A.; Flores-Treviño, S.; Salas-Treviño, D.; Bocanegra-Ibarias, P.; Rivas-Estilla, A.M.; Pérez-Alba, E.; Lozano-Sepúlveda, S.A.; Arellanos-Soto, D.; Camacho-Ortiz, A. Prevalence of SARS-CoV-2 Variants of Concern and Variants of Interest in COVID-19 Breakthrough Infections in a Hospital in Monterrey, Mexico. Viruses 2022, 14, 154. https:// doi.org/10.3390/v14010154 | |
| VIRUS RESPIRATORIOS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos científicos |
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