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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/7870| Characteristics and outcomes of cases of children and adolescents with pediatric inflammatory multisystem syndrome in a tertiary care center in Mexico City | |
| MARÍA DE LOURDES MARROQUÍN YÁÑEZ RODOLFO NORBERTO JIMENEZ JUAREZ VÍCTOR OLIVAR LÓPEZ ADRIÁN CHÁVEZ LÓPEZ JUAN JOSE LUIS SIENRA MONGE LOURDES MARIA DEL CARMEN JAMAICA BALDERAS SILVIA ALEXANDRA MARTÍNEZ HERRERA CLEMEN DOMÍNGUEZ BARRERA JULIO ROBERTO ERDMENGER ORELLANA HORACIO MARQUEZ GONZALEZ MIGUEL KLUNDER KLUNDER JAIME NIETO ZERMEÑO MÓNICA VILLA GUILLEN NADIA GONZALEZ GARCIA MARIA FERNANDA CASTILLA PEON RICARDO GIL GUEVERA | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1101/2021.12.23.21268188 | |
| Background pediatric inflammatory multisystem syndrome (PIMS) is a complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children that resembles Kawasaki syndrome and places them at high risk of cardiorespiratory instability and/or cardiac damage. This study aims to describe the clinical presentation and outcomes of patients with PIMS in Mexico City. Methods This was an observational study of children hospitalized for PIMS based on the Centers for Disease Control and Prevention case definition criteria, in a single tertiary care pediatric center in Mexico City between May 1, 2020, and September 30, 2021. Demographic characteristics, epidemiological data, medical history, laboratory tests, cardiology evaluations, treatment, and clinical outcomes were analyzed. Results Seventy-five cases fulfilled the case definition criteria for PIMS (median age: 10.9 years, Interquartile range [IQR]: 5.6–15.6). Fifteen (20%) patients had a severe underlying disease, 48 (64%) were admitted to the intensive care unit, 33 (44%) required invasive mechanical ventilation and 39 (52%) received vasopressor support. The patients were clustered through latent class analysis based on identified symptoms: Cluster 1 had rash or gastrointestinal symptoms (n = 60) and cluster 2 were those with predominantly respiratory manifestations (n = 15). Two patients (2.7%) died, and both had severe underlying conditions. Five patients (6.7%), all from cluster 1, developed coronary aneurysms. Conclusion There were a high proportion of patients with severe respiratory involvement and positive RT-PCR SARS-CoV-2 and very few cases of coronary aneurysms in our study which suggests that a high proportion of the children had severe acute COVID-19. The clinical manifestations and outcomes are comparable to previously reported international studies. | |
| Medrxiv | |
| 06-03-2022 | |
| Preimpreso | |
| medrxiv.org/ | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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