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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/7840| Diabetes and Mortality Among 1.6 Million Adult Patients Screened for SARS-CoV-2 in Mexico | |
| Juan Castilla Bancayan Orison Woolcott | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1101/2020.11.25.20238345 | |
| Background Whether diabetes is associated with COVID-19-related mortality remains unclear. Methods In this retrospective case-series study we examined the risk of death associated with self-reported diabetes in symptomatic adult patients with laboratory-confirmed COVID-19 who were identified through the System of Epidemiological Surveillance of Viral Respiratory Disease in Mexico from January 1 through November 4, 2020. Survival time was right-censored at 28 days of follow-up. Results Among 757,210 patients with COVID-19 included in the study, 120,476 (16%) had diabetes and 80,616 died. Patients with diabetes had a 49% higher relative risk of death than those without diabetes (Cox proportional-hazard ratio; 1.49 (95% confidence interval [CI], 1.47-1.52), adjusting for age, sex, smoking habit, obesity, hypertension, immunodeficiency, and cardiovascular, pulmonary, and chronic renal disease. The relative risk of death associated with diabetes decreased with age (P=0.004). The hazard ratios were 1.66 (1.58-1.74) in outpatients and 1.14 (1.12-1.16) in hospitalized patients. The 28-day survival for inpatients with and without diabetes was, respectively, 73.5% and 85.2% for patients 20-39 years of age; 66.6% and 75.9% for patients 40-49 years of age; 59.4% and 66.5% for patients 50-59 years of age; 50.1% and 54.6% for patients 60-69 years of age; 42.7% and 44.6% for patients 70-79 years of age; and 38.4% and 39.0% for patients 80 years of age or older. In patients without COVID-19 (878,840), the adjusted hazard ratio for mortality was 1.78 (1.73-1.84). Conclusion In symptomatic adult patients with COVID-19 in Mexico, diabetes was associated with higher mortality. This association decreased with age. | |
| Medrxiv | |
| 26-11-2020 | |
| Preimpreso | |
| medrxiv.org/ | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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| Diabetes and Mortality Among 1.6 Million Adult Patients Screened for SARS-CoV-2 in Mexico.pdf | 582.23 kB | Adobe PDF | Visualizar/Abrir |