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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/778| Clinical characteristics of 2019 novel coronavirus infection in China | |
| Guan, W Ni, Z Hu, Y Liang, W Ou, C He, J Liu, L Shan, H Lei, C Hui, D Du, B Li, L Zeng, G Yuen, K Chen, R Tang, C Wang, T Chen, P Xiang, J Li, S Wang, J Liang, Z Peng, Y Wei, L Liu, Y Peng, P Liu, J Chen, Z Li, G Zheng, Z Qiu, S Luo, J Ye, C Zhu, S Zhong, N | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| Background: Since December 2019, acute respiratory disease (ARD) due to 2019 novel coronavirus (2019-nCoV) emerged in Wuhan city and rapidly spread throughout China. We sought to delineate the clinical characteristics of these cases. Methods: We extracted the data on 1,099 patients with laboratory-confirmed 2019-nCoV ARD from 552 hospitals in 31 provinces/provincial municipalities through January 29th, 2020. Results: The median age was 47.0 years, and 41.90% were females. Only 1.18% of patients had a direct contact with wildlife, whereas 31.30% had been to Wuhan and 71.80% had contacted with people from Wuhan. Fever (87.9%) and cough (67.7%) were the most common symptoms. Diarrhea is uncommon. The median incubation period was 3.0 days (range, 0 to 24.0 days). On admission, ground-glass opacity was the typical radiological finding on chest computed tomography (50.00%). Significantly more severe cases were diagnosed by symptoms plus reverse-transcriptase polymerase-chain-reaction without abnormal radiological findings than non-severe cases (23.87% vs. 5.20%, P<0.001). Lymphopenia was observed in 82.1% of patients. 55 patients (5.00%) were admitted to intensive care unit and 15 (1.36%) succumbed. Severe pneumonia was independently associated with either the admission to intensive care unit, mechanical ventilation, or death in multivariate competing-risk model (sub-distribution hazards ratio, 9.80; 95% confidence interval, 4.06 to 23.67). Conclusions: The 2019-nCoV epidemic spreads rapidly by human-to-human transmission. Normal radiologic findings are present among some patients with 2019-nCoV infection. The disease severity (including oxygen saturation, respiratory rate, blood leukocyte/lymphocyte count and chest X-ray/CT manifestations) predict poor clinical outcomes. | |
| The New England Journal of Medicine | |
| 2020 | |
| Preimpreso | |
| https://coronavirus.1science.com/item/c47fa35b57400893e2e32619ca01622392825d1c | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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