Por favor, use este identificador para citar o enlazar este ítem:
http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/7686| Antibody and memory B-cell immunity in a heterogeneously SARS-CoV-2 infected and vaccinated population | |
| Eva Bednarski PERLA MARIANA DEL RIO ESTRADA Justin DaSilva Celia Boukadida Fengwen Zhang YARA ANDREA LUNA VILLALOBOS Ximena Rodríguez Range ELVIRA PITEN ISIDRO Edgar Luna García Dafne Díaz Rivera DULCE MARIA LOPEZ SANCHEZ Daniela Tapia Trejo MARIBEL SOTO NAVA Myriam Astorga Castañeda José O. Martínez Moreno Guadalupe S. Urbina Granados José A. Jiménez Jacinto Francisco J. Serna Alvarado Yerania E. Enriquez López OLIVA LOPEZ ARELLANO GUSTAVO REYES TERAN Paul Bieniasz SANTIAGO AVILA RIOS Theodora Hatziioannou | |
| Acceso Abierto | |
| Atribución-NoComercial | |
| https://doi.org/10.1101/2022.02.07.22270626 | |
| https://www.medrxiv.org/content/10.1101/2022.02.07.22270626v1 | |
| Global population immunity to SARS-CoV-2 is accumulating through heterogenous combinations of infection and vaccination. Vaccine distribution in low- and middle-income countries has been variable and reliant on diverse vaccine platforms. We studied B-cell immunity in Mexico, a middle-income country where five different vaccines have been deployed to populations with high SARS-CoV-2 incidence. Levels of antibodies that bound a stabilized prefusion spike trimer, neutralizing antibody titers and memory B-cell expansion correlated with each other across vaccine platforms. Nevertheless, the vaccines elicited variable levels of B-cell immunity, and the majority of recipients had undetectable neutralizing activity against the recently emergent omicron variant. SARS-CoV-2 infection, experienced prior to or after vaccination potentiated B-cell immune responses and enabled the generation of neutralizing activity against omicron and SARS-CoV for all vaccines in nearly all individuals. These findings suggest that broad population immunity to SARS-CoV-2 will eventually be achieved, but by heterogenous paths. | |
| medRxiv and bioRxiv | |
| 08-02-2022 | |
| Preimpreso | |
| https://www.medrxiv.org/ | |
| Inglés | |
| Epidemia COVID-19 | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos científicos |
Cargar archivos:
| Fichero | Tamaño | Formato | |
|---|---|---|---|
| Antibody and memory B cell immunity in a heterogeneously SARS COV2 infected and vaccinated population.pdf | 3 MB | Adobe PDF | Visualizar/Abrir |