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Variation in English Covid booster uptake
Greg Dropkin
Acceso Abierto
Atribución-NoComercial
https://doi.org/10.1101/2022.02.01.22270236
https://www.medrxiv.org/content/10.1101/2022.02.01.22270236v1
Introduction: Variable and low takeup of the Covid booster is a recognised problem, associated with age, gender, ethnicity, and deprivation. Are there other relevant predictors? Methods: Data was downloaded from the UK Government Coronavirus Dashboard for Middle Super Output Areas in England, along with demographic, employment, and health data from public sources. Mixed models with a random factor for Upper Tier Local Authority were analysed as quasibinomial Generalized Additive Models, and the estimated random factors were then fitted with Bayesian linear mixed models using flu vaccination uptake, change in public health budgets, vaccination centres, and Region. Results: Models for the MSOA Covid 1st and 2nd vaccinations and the 3rd injection (including the booster), fit the data well. Index of Multiple Deprivation, proportion Aged 15-24 and 25-44, and ethnicity groupings Other White, Indian-Pakistani-Bangladeshi, and African-Caribbean-Other, are highly significant predictors of lower uptake. The estimated random factors vary widely amongst local authorities, and can be predicted by flu vaccine uptake, rise in public health budgets, and regional effects which are positive for London and South East, and negative for North West and North East. Vaccination centres did not reach 90% significance. Discussion: Covid vaccination rates at each stage are very well modeled if local authority random effects are included along with non-linear terms for demographic, employment and health data. Deprivation, younger age, and Other White, South Asian, and Afro-Caribbean ethnicities are associated with lower uptake. Modelling the local effects indicates that increasing public health budgets would improve vaccination uptake.
medRxiv and bioRxiv
01-02-2022
Preimpreso
https://www.medrxiv.org
Inglés
Epidemia COVID-19
Público en general
VIRUS RESPIRATORIOS
Versión publicada
publishedVersion - Versión publicada
Aparece en las colecciones: Artículos científicos

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