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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/7655| Increasing SARS-CoV-2 mutations against vaccination-acquired immunity | |
| Tomokazu Konishi | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1101/2022.01.30.22270133 | |
| https://www.medrxiv.org/content/10.1101/2022.01.30.22270133v1 | |
| Monovalent vaccines using RNA or adenoviruses have successfully controlled the COVID-19 epidemic in many countries. However, viral mutations have hampered the efficacy of this approach. The Omicron variant, in particular, has caused a pandemic which has put pressure on the healthcare system worldwide. Therefore, administration of booster vaccinations has been initiated; however, there are concerns about their effectiveness, sustainability, and possible dangers. There is also the question of how a variant with such isolated mutations originated and whether this is likely to continue in the future. Here, we compare the mutations in the Omicron variant with others by direct PCA to consider questions pertaining to their evolution and characterisation. The Omicron variant, like the other variants, has mutated in its human vectors. The accumulated mutations exceeded the range of acquired immunity, causing a pandemic, and similar mutations are likely to occur in the future. We also compare Omicron with variants that have infected animals and discuss the possibility of a vaccine using a weaker variant of the virus. | |
| medRxiv and bioRxiv | |
| 31-01-2022 | |
| Preimpreso | |
| https://www.medrxiv.org/ | |
| Inglés | |
| Epidemia COVID-19 | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos científicos |
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| increasing SARS COV2 mutations against vaccination acquired immunity.pdf | 1.04 MB | Adobe PDF | Visualizar/Abrir |