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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/763| Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis | |
| Rodriguez-Morales, A Cardona-Ospina, J Gutiérrez-Ocampo, E Villamizar-Peña, R Holguin-Rivera, Y Escalera-Antezana, J Alvarado-Arnez, L Bonilla-Aldana, D Franco-Paredes, C Henao-Martinez, A Paniz-Mondolfi, A Lagos-Grisales, G Ramírez-Vallejo, E Suárez, J Zambrano, L Villamil-Gómez, W Balbin-Ramon, G Rabaan, A Harapan, H Dhama, K Nishiura, H Kataoka, H Ahmad, T Sah, R | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| INTRODUCTION: An epidemic of Coronavirus Disease 2019 (COVID-19) began in December 2019 in China leading to a Public Health Emergency of International Concern (PHEIC). Clinical, laboratory, and imaging features have been partially characterized in some observational studies. No systematic reviews on COVID-19 have been published to date.METHODS: We performed a systematic literature review with meta-analysis, using three databases to assess clinical, laboratory, imaging features, and outcomes of COVID-19 confirmed cases. Observational studies and also case reports, were included, and analyzed separately. We performed a random-effects model meta-analysis to calculate pooled prevalences and 95% confidence intervals (95%CI).RESULTS: 660 articles were retrieved for the time frame (1/1/2020-2/23/2020). After screening, 27 articles were selected for full-text assessment, 19 being finally included for qualitative and quantitative analyses. Additionally, 39 case report articles were included and analyzed separately. For 656 patients, fever (88.7%, 95%CI 84.5-92.9%), cough (57.6%, 95%CI 40.8-74.4%) and dyspnea (45.6%, 95%CI 10.9-80.4%) were the most prevalent manifestations. Among the patients, 20.3% (95%CI 10.0-30.6%) required intensive care unit (ICU), 32.8% presented with acute respiratory distress syndrome (ARDS) (95%CI 13.7-51.8), 6.2% (95%CI 3.1-9.3) with shock. Some 13.9% (95%CI 6.2-21.5%) of hospitalized patients had fatal outcomes (case fatality rate, CFR).CONCLUSION: COVID-19 brings a huge burden to healthcare facilities, especially in patients with comorbidities. ICU was required for approximately 20% of polymorbid, COVID-19 infected patients and hospitalization was associated with a CFR of >13%. As this virus spreads globally, countries need to urgently prepare human resources, infrastructure and facilities to treat severe COVID-19. | |
| Travel Medicine and Infectious Disease | |
| 2020 | |
| Preimpreso | |
| https://coronavirus.1science.com/item/1153bec6249c3fd2ce8c5c8b15193bd928c3c4d9 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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