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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/7605| Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response | |
| Lyudmila Shalamova Ulrike Felgenhauer Andreas R. Schaubmar Kathrin Buettner Marek Widera Sandra Ciesek Friedemann Weber | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1101/2022.01.20.476754 | |
| https://www.biorxiv.org/content/10.1101/2022.01.20.476754v1 | |
| The new variant of concern (VOC) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Omicron (B.1.1.529), is genetically very different from other VOCs. We compared Omicron with the preceding VOC Delta (B.1.617.2) and the wildtype strain (B.1) with respect to their interactions with the antiviral type I interferon (IFN-alpha/beta) response in infected cells. Our data indicate that Omicron has gained an elevated capability to suppress IFN induction upon infection and to better withstand the antiviral state imposed by exogenously added IFN-alpha. | |
| medRxiv and bioRxiv | |
| 20-01-2022 | |
| Preimpreso | |
| www.biorxiv.org | |
| Inglés | |
| Epidemia COVID-19 | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos científicos |
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|---|---|---|---|
| Omicron variant of SARS COV2 exhibits an increased resilience to the antiviral type.pdf | 862.38 kB | Adobe PDF | Visualizar/Abrir |