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Joinpoint Regression to Determine the Impact of COVID-19 on Mortality in Europe: A Longitudinal Analysis From 2000 to 2020 in 27 Countries
Alessandro Rovetta
Acceso Abierto
Atribución-NoComercial-SinDerivadas
https://doi.org/10.1101/2022.01.19.22269576
https://www.medrxiv.org/content/10.1101/2022.01.19.22269576v1
The novel coronavirus disease 2019 (COVID-19) represented the most extensive health emergency in human history. However, to date, there is still a lot of uncertainty about the exact death toll the pandemic has claimed. In particular, the number of official deaths could be vastly underestimated. Despite this, many conspirationists speculate that COVID-19 is not a dangerous disease. Therefore, in this manuscript, we use joinpoint regression analysis to estimate the impact of COVID-19 in 27 European countries by comparing annual mortality trends from 2000 to 2020. Furthermore, we provide accessible evidence even for a non-expert audience. In conclusion, our results estimate that COVID-19 increased the overall mortality in Europe by 10% (P < .001). In 16 out of 27 countries (59.3%), the excess mortality ranged from 7.4% to 18.5% (all P < .007). Comparison of the observed mortality distribution with the null counterfactual showed that the mortality increase was highly significant across Europe, even considering only the nations with minor 2020 increases (highest P = .014, lowest mean = 2.4).
medRxiv and bioRxiv
21-01-2022
Preimpreso
www.medrxiv.org
Inglés
Epidemia COVID-19
Público en general
VIRUS RESPIRATORIOS
Versión publicada
publishedVersion - Versión publicada
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