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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/7594| Evidence of increased Cathepsin B/L and decreased TMPRSS2 usage for cell entry by the SARS-CoV-2 Omicron variant | |
| Pranesh Padmanabhan Narendra Dixit | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1101/2022.01.13.476267 | |
| https://www.biorxiv.org/content/10.1101/2022.01.13.476267v1 | |
| The SARS-CoV-2 Omicron variant appears to exhibit altered cell tropism and entry properties compared to other variants. Here, analysing recent data, we found a strong positive correlation between the entry efficiency of the Omicron variant and the relative usage of the host protease Cathepsin B/L by the original SARS-CoV-2 strain for cell entry. We developed a mathematical model to quantify entry efficiency in in vitro assays and found that the Omicron variant displayed >4-fold improved efficiency in using Cathepsin B/L for entry in 293T-ACE2 cells compared to the original strain. The preferential usage of Cathepsin B/L over TMPRSS2 for entry may explain the altered cell tropism of the Omicron variant and have implications for our understanding of its infectivity and transmissibility as well as for interventions. | |
| medRxiv and bioRxiv | |
| 18-01-2022 | |
| Preimpreso | |
| www.biorxiv.org | |
| Inglés | |
| Epidemia COVID-19 | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos científicos |
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| Fichero | Tamaño | Formato | |
|---|---|---|---|
| Evidence of increased cathepsin B_L and decreased TMPRSS2 usage for cell entry by the SARS COV2 Omicron variant.pdf | 15.78 MB | Adobe PDF | Visualizar/Abrir |