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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/7548| Waning of SARS-CoV-2 booster viral-load reduction effectiveness | |
| Matan Levine-Tiefenbrun Idan Yelin Hillel Alapi Esma Herzel Jacob Kuint Gabriel Chodick Sivan Gazit Tal Patalon Roy Kishony | |
| Acceso Abierto | |
| Atribución-NoComercial | |
| https://doi.org/10.1101/2021.12.27.21268424 | |
| https://www.medrxiv.org/content/10.1101/2021.12.27.21268424v1 | |
| The BNT162b2 COVID-19 vaccine has been shown to reduce viral load of breakthrough infections (BTIs), an important factor affecting infectiousness. This viral-load protective effect has been waning with time post the second vaccine and later restored with a booster shot. It is currently unclear though for how long this regained effectiveness lasts. Analyzing Ct values of SARS-CoV-2 qRT-PCR tests of over 22,000 infections during a Delta-variant-dominant period in Israel, we found that this viral-load reduction effectiveness significantly declines within months post the booster dose. Adjusting for age, sex and calendric date, Ct values of RdRp gene initially increased by 2.7 [CI: 2.3-3.0] relative to unvaccinated in the first month post the booster dose, yet then decayed to a difference of 1.3 [CI: 0.7-1.9] in the second month and became small and insignificant in the third to fourth months. The rate and magnitude of this post-booster decline in viral-load reduction effectiveness mirror those observed post the second vaccine. These results suggest rapid waning of the booster’s effectiveness in reducing infectiousness, possibly affecting community-level spread of the virus. | |
| medRxiv and bioRxiv | |
| 29-12-2021 | |
| Preimpreso | |
| www.medrxiv.org | |
| Inglés | |
| Epidemia COVID-19 | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos científicos |
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| Waning of SARSCOV2 booster viral load reduction effectiveness.pdf | 465.19 kB | Adobe PDF | Visualizar/Abrir |