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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/7527| Micro RNA-based regulation of genomics and transcriptomics of inflammatory cytokines in COVID-19 | |
| Manoj Khokhar SOJIT TOMO PURVI PUROHIT | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1101/2021.06.08.21258565 | |
| https://www.medrxiv.org/content/10.1101/2021.06.08.21258565v1 | |
| Background Coronavirus disease 2019 is characterized by the elevation of a wide spectrum of inflammatory mediators, which are associated with poor disease outcomes. We aimed at an in-silico analysis of regulatory microRNA and their transcription factors (TF) for these inflammatory genes that may help to devise potential therapeutic strategies in the future. Methods The cytokine regulating immune-expressed genes (CRIEG) was sorted from literature and the GEO microarray dataset. Their co-differentially expressed miRNA and transcription factors were predicted from publicly available databases. Enrichment analysis was done through mienturnet, MiEAA, Gene Ontology, and pathways predicted by KEGG and Reactome pathways. Finally, the functional and regulatory features were analyzed and visualized through Cytoscape. | |
| medRxiv and bioRxiv | |
| 12-06-2021 | |
| Preimpreso | |
| www.medrxiv.org | |
| Inglés | |
| Epidemia COVID-19 | |
| Público en general | |
| VIRUS RESPIRATORIOS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos científicos |
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| Micro RNA based regulation of genomics and transcriptomics of inflammatory cytokines in COVID 19.pdf | 2.19 MB | Adobe PDF | Visualizar/Abrir |