Please use this identifier to cite or link to this item: https://covid-19.conacyt.mx/jspui/handle/1000/7385
Occupational versus community risk of SARS-CoV-2 infection among employees of a long-term care facility: an observational study
Lauriane Lenggenhager
Romain Martischang
Julien Sauser
Monica Perez
Laure Vieux
Christophe Graf
Samuel Cordey
Florian Laubscher
Tomas Robalo Nunes
Walter Zingg
Anne Cori
Stephan Harbarth
Mohamed Abbas
Acceso Abierto
Atribución-NoComercial-SinDerivadas
https://doi.org/10.1101/2021.10.22.21265309
https://www.medrxiv.org/content/10.1101/2021.10.22.21265309v1
Objectives: We investigated the relative contribution of occupational (vs. community) exposure for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among employees of a university-affiliated long-term care facility (LTCF), during the 1st pandemic wave in Switzerland (March to June 2020). Methods: We performed a nested analysis of a seroprevalence study among all volunteering LTCF staff to determine community and nosocomial risk factors for SARS-CoV-2 seropositivity using modified Poison regression. We also combined epidemiological and genetic sequencing data from a coronavirus disease 2019 (COVID-19) outbreak investigation in a LTCF ward to infer transmission dynamics and acquisition routes of SARS-CoV-2, and evaluated strain relatedness using a maximum likelihood phylogenetic tree. Results: Among 285 LTCF employees, 176 participated in the seroprevalence study, of whom 30 (17%) were seropositive for SARS-CoV-2. Most (141/176, 80%) were healthcare workers (HCWs). Risk factors for seropositivity included exposure to a COVID-19 inpatient (adjusted prevalence ratio [aPR] 2.6; 95%CI 0.9-8.1) and community contact with a COVID-19 case (aPR 1.7; 95%CI 0.8-3.5). Among 18 employees included in the outbreak investigation, the outbreak reconstruction suggests 4 likely importation events by HCWs with secondary transmissions to other HCWs and patients. Conclusions: These two complementary epidemiologic and molecular approaches suggest a substantial contribution of both occupational and community exposures to COVID-19 risk among HCWs in LTCFs. These data may help to better assess the importance of occupational health hazards and related legal implications during the COVID-19 pandemic.
medRxiv
22-10-2021
Preimpreso
Medrxiv
Inglés
Epidemia COVID-19
Estudiantes
Investigadores
Medios de comunicación
Otros
Público en general
VIRUS RESPIRATORIOS
Versión publicada
publishedVersion - Versión publicada
Appears in Collections:Artículos científicos

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