Please use this identifier to cite or link to this item: https://covid-19.conacyt.mx/jspui/handle/1000/736
A Sequence Homology and Bioinformatic Approach Can Predict Candidate Targets for Immune Responses to SARS-CoV-2
Grifoni, A
Sidney, J
Zhang, Y
Scheuermann, R
Peters, B
Sette, A
Acceso Abierto
Atribución-NoComercial-SinDerivadas
Effective countermeasures against the recent emergence and rapid expansion of the 2019 novel coronavirus (SARS-CoV-2) require the development of data and tools to understand and monitor its spread and immune responses to it. However, little information is available about the targets of immune responses to SARS-CoV-2. We used the Immune Epitope Database and Analysis Resource (IEDB) to catalog available data related to other coronaviruses. This includes SARS-CoV, which has high sequence similarity to SARS-CoV-2 and is the best-characterized coronavirus in terms of epitope responses. We identified multiple specific regions in SARS-CoV-2 that have high homology to the SARS-CoV virus. Parallel bioinformatic predictions identified a priori potential B and Tcell epitopes for SARS-CoV-2. The independent identification of the same regions using two approaches reflects the high probability that these regions are promising targets for immune recognition of SARS-CoV-2. These predictions can facilitate effective vaccine design against this virus of high priority.
Cell Host & Microbe
2020
Preimpreso
https://coronavirus.1science.com/item/4f918778baaf83a5e0c780ac12fca22a875ed87a
Inglés
VIRUS RESPIRATORIOS
Appears in Collections:Artículos científicos

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