Please use this identifier to cite or link to this item: https://covid-19.conacyt.mx/jspui/handle/1000/7339
The evolutionary landscape of SARS-CoV-2 variant B.1.1.519 and its clinical impact in Mexico City
ALBERTO CEDRO TANDA
Laura Gómez-Romero
NICOLAS ALCARAZ MILLMAN
GUILLERMO DE ANDA JAUREGUI
FERNANDO PEÑALOZA FIGUEROA
BERNARDO MORENO QUIROGA
Marco Armando Escobar Arrazola
Oscar A. Ramírez Vega
MIREYA CISNEROS VILLANUEVA
José L. Moreno Camacho
Jorge Rodriguez Gallegos
Marco Luna-Ruiz Esparza
Miguel Fernández-Rojas
ALFREDO MENDOZA VARGAS
JUAN PABLO REYES GRAJEDA
ABRAHAM CAMPOS ROMERO
Ofelia Angulo
ROSAURA RUIZ GUTIERREZ
CLAUDIA SHEINBAUM PARDO
JOSE SIFUENTES OSORNIO
David Kershenobich Stalnikowitz
ALFREDO HIDALGO MIRANDA
LUIS ALONSO HERRERA MONTALVO
Acceso Abierto
Atribución-NoComercial-SinDerivadas
https://doi.org/10.1101/2021.09.07.21262911
https://www.medrxiv.org/content/10.1101/2021.09.07.21262911v1
The SARS-CoV-2 pandemic is one of the most concerning health problems around the globe. We report the emergence of SARS-CoV-2 variant B.1.1.519 in Mexico City. This variant represented up to 90% of sequenced cases in February 2021. It is characterized by three amino acid changes in the spike protein: T478K, P681H, and T732A. We report the effective reproduction number of B.1.1.519 and present evidence of its geographical origin based on phylogenetic analysis. We also studied its evolution via haplotype analysis and identified the most recurrent haplotypes. Finally, we studied the clinical impact of B.1.1.519: patients infected with variant B.1.1.519 showed a highly significant adjusted odds ratio (aOR) increase of 1.85 over non-B.1.1.519 patients for developing a severe/critical outcome (P = 0.000296, 1.33-2.6 95% CI) and a 2.35-fold increase for hospitalization (P = 0.005, 1.32-4.34 95% CI). The continuous monitoring of this and other variants will be required to control the ongoing pandemic as it evolves.
medRxiv
07-09-2021
Preimpreso
www.medrxiv.org
Inglés
Epidemia COVID-19
Estudiantes
Investigadores
Público en general
VIRUS RESPIRATORIOS
Versión publicada
publishedVersion - Versión publicada
Appears in Collections:Artículos científicos

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