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Persistence of neutralizing antibodies a year after SARS-CoV-2 infection
Anu Haveri
Nina Ekstrom
Anna Solastie
Camilla Virta
Pamela Österlund
Elina Isosaari
Hanna Nohynek
Arto Palmu
Merit Melin
Acceso Abierto
Understanding for how long antibodies persist following Severe acute respiratory coronavirus 2 (SARS-CoV-2) infection provides important insight into estimating the duration of immunity induced by infection. We assessed the persistence of serum antibodies following wild-type SARS-CoV-2 infection six and twelve months after diagnosis in 367 individuals of whom 13% had severe disease requiring hospitalization. We determined the SARS-CoV-2 spike (S-IgG) and nucleoprotein IgG concentrations and the proportion of subjects with neutralizing antibodies (NAb). We also measured the NAb titers among a smaller subset of participants (n=78) against a wild-type virus (B.1) and three variants of concern (VOCs): Alpha (B.1.1.7), Beta (B.1.351) and Delta (B.1.617.2). We found that NAb against the wild-type virus and S-IgG persisted in 89% and 97% of subjects for at least twelve months after infection, respectively. IgG and NAb levels were higher after severe infection. NAb titers were significantly lower against variants compared to the wild-type virus.
Epidemia COVID-19
Público en general
Versión publicada
publishedVersion - Versión publicada
Appears in Collections:Artículos científicos

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