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The importance of saturating density dependence for predicting SARS-CoV-2 resurgence
Nightingale Emily .
Oliver J. Brady
Laith Yakob
Acceso Abierto
Atribución-NoComercial-SinDerivadas
https://doi.org/10.1101/2020.08.28.20183921
https://www.medrxiv.org/content/10.1101/2020.08.28.20183921v1
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted more effectively in densely populated areas and omitting this phenomenon from epidemiological models may substantially affect projections of spread and control. Adjusting for deprivation, proportion of ethnic minority population and proportion of key workers among the working population, mortality data from England show good evidence for an increasing trend with population density until a saturating level. Projections from a mathematical model that accounts for this observation deviate markedly from the current status quo for SARS-CoV-2 models which either assume linearity between density and transmission (30% of models) or no relationship at all (70%). Respectively, these standard model structures over- and under-estimate the delay in infection resurgence following the release of lockdown. Models have had a prominent role in SARS-CoV-2 intervention strategy; identifying saturation points for given populations and including transmission terms that account for this feature will improve model utility.
https://www.medrxiv.org/
01-09-2020
Preimpreso
https://www.medrxiv.org
Inglés
Epidemia COVID-19
Público en general
VIRUS RESPIRATORIOS
Versión publicada
publishedVersion - Versión publicada
Aparece en las colecciones: Artículos científicos

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