Please use this identifier to cite or link to this item:
Kinetics of SARS-CoV-2 specific IgM and IgG responses in COVID-19 patients
Baoqing Sun
Ying Feng
Xiaoneng Mo
Peiyan Zheng
Qian Wang
Pingchao Li
Ping Peng
Xiaoqing Liu
Zhilong Chen
Huimin Huang
Fan Zhang
Wenting Luo
Xuefeng Niu
Peiyu Hu
Longyu Wang
Hui Peng
Zhifeng Huang
Liqiang Feng
Feng Li
Fuchun Zhang
Fang Li
Nanshan Zhong
Ling Chen
Novel Coronavirus
Acceso Abierto
C-reactive protein
The emerging COVID-19 caused by SARS-CoV-2 infection poses severe challenges to global public health. Serum antibody testing is becoming one of the critical methods for the diagnosis of COVID-19 patients. We investigated IgM and IgG responses against SARS-CoV-2 nucleocapsid (N) and spike (S) protein after symptom onset in the intensive care unit (ICU) and non-ICU patients. 130 blood samples from 38 COVID-19 patients were collected. The levels of IgM and IgG specific to N and S protein were detected by ELISA. A series of blood samples were collected along the disease course from the same patient, including 11 ICU patients and 27 non-ICU patients for longitudinal analysis. N and S specific IgM and IgG (N-IgM, N-IgG, S-IgM, S-IgG) in non-ICU patients increased after symptom onset. N-IgM and S-IgM in some non-ICU patients reached a peak in the second week, while N-IgG and S-IgG continued to increase in the third week. The combined detection of N and S specific IgM and IgG could identify up to 75% of SARS-CoV-2 infected patients in the first week. S-IgG was significantly higher in non-ICU patients than in ICU patients in the third week. In contrast, N-IgG was significantly higher in ICU patients than in non-ICU patients. The increase of S-IgG positively correlated with the decrease of C-reactive protein (CRP) in non-ICU patients. N and S specific IgM and IgG increased gradually after symptom onset and can be used for detection of SARS-CoV-2 infection. Analysis of the dynamics of S-IgG may help to predict prognosis.
Emerging Microbes & Infections
Epidemia COVID-19
Versión publicada
publishedVersion - Versión publicada
Appears in Collections:Artículos científicos

Upload archives