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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/6805| Delayed specific IgM antibody responses observed among COVID-19 patients with severe progression | |
| Liang Shen Chunhua Wang Jianzhong Zhao Xiaoyong Tang Ying Shen Mingqing Lu Zhe Ding Canping Huang Ji Zhang Shichao Li Jiaming Lan Gary Wong Yufang Zhu | |
| Novel Coronavirus | |
| Acceso Abierto | |
| Atribución | |
| https://doi.org/10.1080/22221751.2020.1766382 | |
| GICA Delayed IgM antibody COVID-19 | |
| Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly worldwide since it was confirmed as the causative agent of COVID-19. Molecular diagnosis of the disease is typically performed via nucleic acid-based detection of the virus from swabs, sputum or bronchoalveolar lavage fluid (BALF). However, the positive rate from the commonly used specimens (swabs or sputum) was less than 75%. Immunological assays for SARS-CoV-2 are needed to accurately diagnose COVID-19. Sera were collected from patients or healthy people in a local hospital in Xiangyang, Hubei Province, China. The SARS-CoV-2 specific IgM antibodies were then detected using a SARS-CoV-2 IgM colloidal gold immunochromatographic assay (GICA). Results were analysed in combination with sera collection date and clinical information. The GICA was found to be positive with the detected 82.2% (37/45) of RT-qPCR confirmed COVID-19 cases, as well as 32.0% (8/25) of clinically confirmed, RT-qPCR negative patients (4–14 days after symptom onset). Investigation of IgM-negative, RT-qPCR-positive COVID-19 patients showed that half of them developed severe disease. The GICA was found to be a useful test to complement existing PCR-based assays for confirmation of COVID-19, and a delayed specific IgM antibody response was observed among COVID-19 patients with severe progression. | |
| Emerging Microbes & Infections | |
| 01-06-2020 | |
| Artículo | |
| https://www.tandfonline.com/doi/full/10.1080/22221751.2020.1766382?scroll=top&needAccess=true | |
| Inglés | |
| Epidemia COVID-19 | |
| Investigadores | |
| VIRUS RESPIRATORIOS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos científicos |
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