Please use this identifier to cite or link to this item: https://covid-19.conacyt.mx/jspui/handle/1000/599
New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?
Devaux, C
Rolain, J
Colson, P
Raoult, D
Acceso Abierto
Atribución-NoComercial-SinDerivadas
Recently, a novel coronavirus (2019-nCoV), officially known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China. Despite drastic containment measures, the spread of this virus is ongoing. SARS-CoV-2 is the aetiological agent of coronavirus disease 2019 (COVID-19) characterised by pulmonary infection in humans. The efforts of international health authorities have since focused on rapid diagnosis and isolation of patients as well as the search for therapies able to counter the most severe effects of the disease. In the absence of a known efficient therapy and because of the situation of a public-health emergency, it made sense to investigate the possible effect of chloroquine/hydroxychloroquine against SARS-CoV-2 since this molecule was previously described as a potent inhibitor of most coronaviruses, including SARS-CoV-1. Preliminary trials of chloroquine repurposing in the treatment of COVID-19 in China have been encouraging, leading to several new trials. Here we discuss the possible mechanisms of chloroquine interference with the SARS-CoV-2 replication cycle.
International Journal of Antimicrobial Agents
2020
Preimpreso
https://coronavirus.1science.com/item/49d61abd5a2aac3b63f268f282cf93f8c84a1d19
Inglés
VIRUS RESPIRATORIOS
Appears in Collections:Artículos científicos

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