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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/5503| The correlation between viral clearance and biochemical outcomes of 94 COVID-19 infected discharged patients | |
| Yuan Jing. Zou Rougrong. Zeng Lijiao. Kou Shanglong. Lan Jianfeng. Li Xiaohe. Liang Yanhua. Ding Xiaoyan. Tan Guoyu. Tang Shenghong. Liu Lei. Liu Yingxia. Pan Yanchao. Wang Zhaoqin. | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1007/s00011-020-01342-0 | |
| OBJECTIVE:This study aims to evaluate the correlation between viral clearance and blood biochemical index of 94 discharged patients with COVID-19 infection in Shenzhen Third People's Hospital, enrolled from Jan 5 to Feb 13, 2020. METHODS:The clinical and laboratory findings were extracted from the electronic medical records of the patients. The data were analysed and reviewed by a trained team of physicians. Information on clinical signs and symptoms, medical treatment, virus clearance, and laboratory parameters including interleukin 6 (IL-6) and C-reactive protein were collected. RESULTS:COVID-19 mRNA clearance ratio was identified significantly correlated with the decline of serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels. Furthermore, COVID-19 mRNA clearance time was positively correlated with the length of hospital stay in patients treated with either IFN-α + lopinavir/ritonavir or IFN-α + lopinavir/ritonavir + ribavirin. CONCLUSIONS:Therapeutic regimens of IFN-α + lopinavir/ritonavir and IFN-α + lopinavir/ritonavir + ribavirin might be beneficial for treatment of COVID-19. Serum LDH or CK decline may predict a favorable response to treatment of COVID-19 infection. | |
| Inflammation Research | |
| 2020 | |
| Artículo | |
| https://link.springer.com/content/pdf/10.1007/s00011-020-01342-0.pdf | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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